Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators
IntroductionCystic Fibrosis (CF) is a genetic disease due to loss-of-function mutations of the CFTR channel. F508del is the most frequent mutation (70% of alleles in Italy), while other mutations have much lower frequency. Among them, G85E (0.4% frequency globally, 1.13% in Italy) emerges as a mutat...
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2024-11-01T00:00:00Z.
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