Shikonin Directly Inhibits Nitric Oxide Synthases: Possible Targets That Affect Thoracic Aorta Relaxation Response and Nitric Oxide Release From RAW 264.7 Macrophages

• Main Authors: Lucia S. Yoshida (Author), Tomie Kawada (Author), Kaoru Irie (Author), Yasukatsu Yuda (Author), Toshiyuki Himi (Author), Fumihiko Ikemoto (Author), Hiromi Takano-Ohmuro (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently, an isomeric mixture of herbal anti-inflammatory naphthoquinones shikonin and alkannin, and their derivatives, have been found to impair cellular responses involving nitric oxide (NO) and NO synthesis, like the acetylcholine-induced relaxation response of rat thoracic aorta and NO release f...