Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal <i>Caenorhabditis elegans</i>/<i>Galleria mellonella</i> Sequential-Screening Approach

• Main Authors: Rajamohammed Khader (Author), Nagendran Tharmalingam (Author), Biswajit Mishra (Author), LewisOscar Felix (Author), Frederick M. Ausubel (Author), Michael J. Kelso (Author), Eleftherios Mylonakis (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is a significant need to combat the growing challenge of antibacterial drug resistance. We have previously developed a whole-animal dual-screening platform that first used the nematode <i>Caenorhabditis elegans</i>, to identify low-toxicity antibacterial hits in a high-throughput f...