Loss of ACTL7A causes small head sperm by defective acrosome-acroplaxome-manchette complex

• Main Authors: Yini Zhang (Author), Jianan Tang (Author), Xuemei Wang (Author), Yisi Sun (Author), Tianying Yang (Author), Xiaorong Shen (Author), Xinyue Yang (Author), Huijuan Shi (Author), Xiaoxi Sun (Author), Aijie Xin (Author)
• Format: Book
• Published: BMC, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Actin-like 7 A (ACTL7A) is essential for acrosome formation, fertilization and early embryo development. ACTL7A variants cause acrosome detachment responsible for male infertility and early embryonic arrest. In this study, we aim to explore the additional functions of ACTL7A beyo...