Receptor of Advanced Glycation End Products Deficiency Attenuates Cisplatin-Induced Acute Nephrotoxicity by Inhibiting Apoptosis, Inflammation and Restoring Fatty Acid Oxidation

• Main Authors: Qiang Wang (Author), Yuemei Xi (Author), Binyang Chen (Author), Hairong Zhao (Author), Wei Yu (Author), De Xie (Author), Weidong Liu (Author), Furong He (Author), Chenxi Xu (Author), Jidong Cheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin is a widely used and potent anti-neoplastic agent, but severe and inescapable side effects in multiple normal tissues and organs limit its application, especially nephrotoxicity. Molecular mechanisms of cisplatin nephrotoxicity involve mitochondrial damage, oxidative stress, endoplasmic re...