Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve

• Main Authors: Hidetoshi Kaburagi (Author), Tetsuya Nagata (Author), Mitsuhiro Enomoto (Author), Takashi Hirai (Author), Masaki Ohyagi (Author), Kensuke Ihara (Author), Kie Yoshida-Tanaka (Author), Satoe Ebihara (Author), Ken Asada (Author), Hiroyuki Yokoyama (Author), Atsushi Okawa (Author), Takanori Yokota (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuropathic pain, a heterogeneous condition, affects 7%-10% of the general population. To date, efficacious and safe therapeutic approaches remain limited. Antisense oligonucleotide (ASO) therapy has opened the door to treat spinal muscular atrophy, with many ongoing clinical studies determining its...