Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy

• Main Authors: Jiang Yu (Author), Yingli Wang (Author), Shuang Zhou (Author), Jinbo Li (Author), Jiamei Wang (Author), Dongxu Chi (Author), Xue Wang (Author), Guimei Lin (Author), Zhonggui He (Author), Yongjun Wang (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The combination of paclitaxel (PTX) and doxorubicin (DOX) has been widely used in the clinic. However, it remains unsatisfied due to the generation of severe toxicity. Previously, we have successfully synthesized a prodrug PTX-S-DOX (PSD). The prodrug displayed comparable in vitro cytotoxicity compa...