Translating a Thin-Film Rehydration Method to Microfluidics for the Preparation of a SARS-CoV-2 DNA Vaccine: When Manufacturing Method Matters

• Main Authors: Allegra Peletta (Author), Eakachai Prompetchara (Author), Kittipan Tharakhet (Author), Papatsara Kaewpang (Author), Supranee Buranapraditkun (Author), Nongnaphat Yostrerat (Author), Suwimon Manopwisedjaroen (Author), Arunee Thitithanyanont (Author), Jonathan Avaro (Author), Leonard Krupnik (Author), Antonia Neels (Author), Kiat Ruxrungtham (Author), Chutitorn Ketloy (Author), Gerrit Borchard (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous investigations conducted on a liposomal formulation for a SARS-CoV-2 DNA vaccine manufactured using the thin-film layer rehydration method showed promising immunogenicity results in mice. The adaptation of the liposomal formulation to a scalable and reproducible method of manufacture is nec...