A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.

• Main Authors: Yoshimi Tsuda (Author), Patrizia Caposio (Author), Christopher J Parkins (Author), Sara Botto (Author), Ilhem Messaoudi (Author), Luka Cicin-Sain (Author), Heinz Feldmann (Author), Michael A Jarvis (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immu...