Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy

• Main Authors: Renming Fan (Author), Ruizhuo Lin (Author), Shuo Zhang (Author), Aohua Deng (Author), Yongrui Hai (Author), Junyan Zhuang (Author), Yang Liu (Author), Maosheng Cheng (Author), Gaofei Wei (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial membrane remodeling can trigger the release of mitochondrial DNA (mtDNA), leading to the activation of cellular oxidative stress and immune responses. While the role of mitochondrial membrane remodeling in promoting inflammation in hepatocytes is well-established, its effects on tumors...