Hepcidin antagonists for potential treatments of disorders with hepcidin excess

• 主要な著者: Poli eMaura (著者), Michela easperti (著者), Paola eRuzzenenti (著者), Maria eRegoni (著者), Paolo eArosio (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide. Hepcidin binds ferroportin, the only cellular iron exporter, causing the internalizatio...