Hepcidin antagonists for potential treatments of disorders with hepcidin excess

• Main Authors: Poli eMaura (Author), Michela easperti (Author), Paola eRuzzenenti (Author), Maria eRegoni (Author), Paolo eArosio (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide. Hepcidin binds ferroportin, the only cellular iron exporter, causing the internalizatio...