Population Pharmacokinetics Analysis of Amikacin Initial Dosing Regimen in Elderly Patients

• Váldodahkkit: Hideo Kato (Dahkki), Suzanne L. Parker (Dahkki), Jason A. Roberts (Dahkki), Mao Hagihara (Dahkki), Nobuhiro Asai (Dahkki), Yuka Yamagishi (Dahkki), David L. Paterson (Dahkki), Hiroshige Mikamo (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2021-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

There are limited data of amikacin pharmacokinetics (PK) in the elderly population. Hence, we aimed to describe the population PK of amikacin in elderly patients (>70 years old) and to establish optimized initial dosing regimens. We simulated individual maximum concentrations in plasma (Cmax) and...