Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells

• Autori principali: Liang Yan (Autore), Yi Liu (Autore), Xue-feng Ma (Autore), Dan Hou (Autore), Yu-hui Zhang (Autore), Yong Sun (Autore), Shan-shan Shi (Autore), Tim Forouzanfar (Autore), Hai-yan Lin (Autore), Jun Fan (Autore), Gang Wu (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Pyroptosis is a form of programmed cell death, in which gasdermin E (GSDME) plays an important role in cancer cells, which can be induced by activated caspase-3 on apoptotic stimulation. Triclabendazole is a new type of imidazole in fluke resistance and has been approved by the FDA for the treatment...