Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells

• Main Authors: Liang Yan (Author), Yi Liu (Author), Xue-feng Ma (Author), Dan Hou (Author), Yu-hui Zhang (Author), Yong Sun (Author), Shan-shan Shi (Author), Tim Forouzanfar (Author), Hai-yan Lin (Author), Jun Fan (Author), Gang Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pyroptosis is a form of programmed cell death, in which gasdermin E (GSDME) plays an important role in cancer cells, which can be induced by activated caspase-3 on apoptotic stimulation. Triclabendazole is a new type of imidazole in fluke resistance and has been approved by the FDA for the treatment...