Characterization of novel dual tandem CD19/BCMA chimeric antigen receptor T cells to potentially treat multiple myeloma

• Main Authors: Liqing Kang (Author), Jian Zhang (Author), Minghao Li (Author), Nan Xu (Author), Wei Qi (Author), Jingwen Tan (Author), Xiaoyan Lou (Author), Zhou Yu (Author), Juanjuan Sun (Author), Zhenkun Wang (Author), Chengcheng Fu (Author), Xiaowen Tang (Author), Haiping Dai (Author), Jia Chen (Author), Depei Wu (Author), Lei Yu (Author)
• Format: Book
• Published: BMC, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Treatment with chimeric antigen receptor (CAR)-engineered T cells directed against the B-cell maturation antigen (BCMA) promoted transient recovery from multiple myeloma (MM). However, the absence of this antigen on immature plasma cells may limit the efficacy of this modality an...