Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients

• Hlavní autoři: M. Vomero (Autor), M. Caliste (Autor), C. Barbati (Autor), M. Speziali (Autor), A. I. Celia (Autor), F. Ucci (Autor), C. Ciancarella (Autor), E. Putro (Autor), T. Colasanti (Autor), G. Buoncuore (Autor), E. Corsiero (Autor), M. Bombardieri (Autor), F. R. Spinelli (Autor), F. Ceccarelli (Autor), F. Conti (Autor), C. Alessandri (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

The pathway of Janus tyrosine kinases (JAKs) has a central role in the pathogenesis of Rheumatoid Arthritis (RA) by regulating multiple immune functions and cytokine production. The JAK inhibitor tofacitinib is effective in RA patients not responding to methotrexate or TNF-inhibitors. Since hyperact...