Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin

• Main Authors: Sonia Golombek (Author), Martin Pilz (Author), Heidrun Steinle (Author), Efrat Kochba (Author), Yotam Levin (Author), Dominique Lunter (Author), Christian Schlensak (Author), Hans Peter Wendel (Author), Meltem Avci-Adali (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years, synthetic mRNA-based applications to produce desired exogenous proteins in cells have been gaining importance. However, systemic delivery of synthetic mRNA can result in unspecific uptake into undesired cells or organs and, thereby, fail to target desired cells. Thus, local and targ...