Dual Function of Wnt Signaling during Neuronal Differentiation of Mouse Embryonic Stem Cells

• 主要な著者: Hanjun Kim (著者), Sewoon Kim (著者), Yonghee Song (著者), Wantae Kim (著者), Qi-Long Ying (著者), Eek-hoon Jho (著者)
• フォーマット: 図書
• 出版事項: Hindawi Limited, 2015-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Activation of Wnt signaling enhances self-renewal of mouse embryonic and neural stem/progenitor cells. In contrast, undifferentiated ES cells show a very low level of endogenous Wnt signaling, and ectopic activation of Wnt signaling has been shown to block neuronal differentiation. Therefore, it rem...