Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

• Главные авторы: Tessianna A. Misko (Автор), Yi-Ting Liu (Автор), Michael E. Harris (Автор), Nancy L. Oleinick (Автор), John Pink (Автор), Hsueh-Yun Lee (Автор), Chris G. Dealwis (Автор)
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• Опубликовано: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Предметы: article
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Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl hydrazone-based inhibitor (NSAH) that binds reversi...