Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

• Main Authors: Tessianna A. Misko (Author), Yi-Ting Liu (Author), Michael E. Harris (Author), Nancy L. Oleinick (Author), John Pink (Author), Hsueh-Yun Lee (Author), Chris G. Dealwis (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl hydrazone-based inhibitor (NSAH) that binds reversi...