VEGF Overexpression Significantly Increases Nanoparticle-Mediated siRNA Delivery and Target-Gene Downregulation

• Main Authors: Shanshan Tan (Author), Zhihang Chen (Author), Yelena Mironchik (Author), Noriko Mori (Author), Marie-France Penet (Author), Ge Si (Author), Balaji Krishnamachary (Author), Zaver M. Bhujwalla (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The availability of nanoparticles (NPs) to deliver small interfering RNA (siRNA) has significantly expanded the specificity and range of 'druggable' targets for precision medicine in cancer. This is especially important for cancers such as triple negative breast cancer (TNBC) for which the...