Combinatorial Inhibition of Cell Surface Receptors Using Dual Aptamer-Functionalized Nanoconstructs for Cancer Treatment

• Main Authors: Hyojin Lee (Author), Tae Hee Kim (Author), Daechan Park (Author), Mihue Jang (Author), Justin J. Chung (Author), Soo Hyun Kim (Author), Sang-Heon Kim (Author), Kwan Hyi Lee (Author), Youngmee Jung (Author), Seung Ja Oh (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Membrane receptors overexpressed in diseased states are considered novel therapeutic targets. However, the single targeting approach faces several fundamental issues, such as poor efficacy, resistance, and toxicity. Here, we report a dual-targeting strategy to enhance anti-cancer efficacy via synerg...