Cytochrome P450 1A2 Is Incapable of Oxidizing Bilirubin Under Physiological Conditions

• Main Authors: Xinyi Li (Author), Dongzhen Yu (Author), Huiqun Jie (Author), Huiqun Zhou (Author), Haibo Ye (Author), Guo Ma (Author), Lili Wan (Author), Chunyan Li (Author), Haibo Shi (Author), Shankai Yin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver. Some studies have shown that several subtypes of cytochrome P450 (CYP) enzymes, including CYP1A2, are upregulated by inducers and proposed to be al...