Design, synthesis, 2D-QSAR, molecular dynamic simulation, and biological evaluation of topiramate-phenolic acid conjugates as PPARγ inhibitors

Abstract Background Obesity is a precursor for many co-morbid diseases. One of the main triggering factors for obesity is the abnormal expansion of white adipose tissue characterized by high rates of genesis and differentiation of precursor cells into mature adipocytes. As a result, targeting adipog...

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Main Authors: Ipsa Padhy (Author), Biswajit Banerjee (Author), P. Ganga Raju Achary (Author), Pramodkumar P. Gupta (Author), Tripti Sharma (Author)
Format: Book
Published: SpringerOpen, 2024-03-01T00:00:00Z.
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