Development and Characterization of Eudragit^® EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity

• Main Authors: Sana Inam (Author), Muhammad Irfan (Author), Noor ul ain Lali (Author), Haroon Khalid Syed (Author), Sajid Asghar (Author), Ikram Ullah Khan (Author), Salah- (Author), Muhammad Shahid Iqbal (Author), Imran Zaheer (Author), Ahmed Khames (Author), Heba A. Abou-Taleb (Author), Mohammad A. S. Abourehab (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid dispersion (SD) is a promising technology for improving dissolution and, thereby, the bioavailability of poorly soluble d...