A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90

• Main Authors: Vy Ngo (Author), Anne Brickenden (Author), Hansen Liu (Author), Cynthia Yeung (Author), Wing-Yiu Choy (Author), Martin L. Duennwald (Author)
• Format: Book
• Published: The Company of Biologists, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It is chiefly regulated by Keap1, a substrate adaptor protein that mediates Nrf2 degradation. Nrf2 activity is also influenced by many other protein interactions that provide Keap1-independent regulation. To...