Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes

• Main Authors: Ahmed El‐Boraie (Author), Julie‐Anne Tanner (Author), Andy Z.X. Zhu (Author), Katrina G. Claw (Author), Bhagwat Prasad (Author), Erin G. Schuetz (Author), Kenneth E. Thummel (Author), Koya Fukunaga (Author), Taisei Mushiroda (Author), Michiaki Kubo (Author), Neal L. Benowitz (Author), Caryn Lerman (Author), Rachel F. Tyndale (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking‐related disease risk. The heritability of the NMR is 60-80%, yet weighted genetic risk scores (wGRSs) based on common variants explain only 30-35%...