Wilson disease, ABCC2 c.3972C > T polymorphism and primary liver cancers: suggestions from a familial cluster

• Main Authors: Giovanni Brandi (Author), Alessandro Rizzo (Author), Marzia Deserti (Author), Valeria Relli (Author), Valentina Indio (Author), Sofia Bin (Author), Milena Pariali (Author), Andrea Palloni (Author), Stefania De Lorenzo (Author), Francesco Tovoli (Author), Simona Tavolari (Author)
• Format: Book
• Published: BMC, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Polymorphisms in genes modulating xenobiotics metabolism, in particular the ABCC2 c.3972C > T single nucleotide polymorphism (SNP) at exon 28, have been suggested to increase primary liver cancer (PLC) risk. Conversely, the occurrence of PLCs in Wilson disease patients is a ra...