Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice

• Main Authors: Camille Allard (Author), Fabrice Bonnet (Author), Beibei Xu (Author), Laurel Coons (Author), Diana Albarado (Author), Cristal Hill (Author), Guy Fagherazzi (Author), Kenneth S. Korach (Author), Ellis R. Levin (Author), John Lefante (Author), Christopher Morrison (Author), Franck Mauvais-Jarvis (Author)
• Format: Book
• Published: Elsevier, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The endogenous estrogen 17β-estradiol (E2) promotes metabolic homeostasis in premenopausal women. In a mouse model of post-menopausal metabolic syndrome, we reported that estrogens increased energy expenditure, thus preventing estrogen deficiency-induced adiposity. Estrogens' prevent...