Preclinical Studies in the mdx Mouse Model of Duchenne Muscular Dystrophy with the Histone Deacetylase Inhibitor Givinostat

Preclinical Studies in the mdx Mouse Model of Duchenne Muscular Dystrophy with the Histone Deacetylase Inhibitor Givinostat

Abstract Previous work has established the existence of dystrophin-nitric oxide (NO) signaling to histone deacetylases (HDACs) that is deregulated in dystrophic muscles. As such, pharmacological interventions that target HDACs (that is, HDAC inhibitors) are of potential therapeutic interest for the...

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Main Authors: Silvia Consalvi (Author), Chiara Mozzetta (Author), Paolo Bettica (Author), Massimiliano Germani (Author), Francesco Fiorentini (Author), Francesca Del Bene (Author), Maurizio Rocchetti (Author), Flavio Leoni (Author), Valmen Monzani (Author), Paolo Mascagni (Author), Pier Lorenzo Puri (Author), Valentina Saccone (Author)
Format: Book
Published: BMC, 2013-03-01T00:00:00Z.
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