Endogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative stress in Trypanosoma cruzi.

• Main Authors: Diego A Rojas (Author), Fabiola Urbina (Author), Sandra Moreira-Ramos (Author), Christian Castillo (Author), Ulrike Kemmerling (Author), Michel Lapier (Author), Juan Diego Maya (Author), Aldo Solari (Author), Edio Maldonado (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria (kinetoplast), where specific protein complexes detect and eliminate damage to DNA. O...