In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model
We assessed electrophysiological effects of an atypical antipsychotic drug paliperidone in acute atrioventricular block rabbits. Intravenous administration of paliperidone at a clinically relevant dose (0.06 mg/kg) hardly affected the QT interval or monophasic action potential (MAP) duration, and th...
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Main Authors: | Mihoko Hagiwara (Author), Ryuichi Kambayashi (Author), Megumi Aimoto (Author), Yoshinobu Nagasawa (Author), Akira Takahara (Author) |
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Format: | Book |
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Elsevier,
2016-09-01T00:00:00Z.
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