Study on the possible role of the -174G>C IL-6 promoter polymorphism in predicting response to rituximab in rheumatoid arthritis

• Main Authors: F. Fischetti (Author), L.M. Bambara (Author), A. Carletto (Author), M. Cutolo (Author), P. Sarzi-Puttini (Author), R. Pellerito (Author), C. Fabro (Author), E. Pontarini (Author), M.A. Cimmino (Author), P. Morassi (Author), F. Atzeni (Author), M. Saracco (Author), M. Manfredi (Author), M. Benucci (Author), S. Lombardi (Author), L. Quartuccio (Author), M. Fabris (Author), F. Curcio (Author), E. Tonutti (Author), S. De VIta (Author)
• Format: Book
• Published: PAGEPress Publications, 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several studies demonstrated the efficacy of the B-cell depletion therapy with rituximab (RTX) in RA patients, including those unresponsive to anti- TNF therapy, underlying the important role of B cells in this disease (1-5). Several recent papers have demonstrated a differential effects of RTX in d...