Extracellular Vesicles from M1-Polarized Macrophages Combined with Hyaluronic Acid and a β-Blocker Potentiate Doxorubicin's Antitumor Activity by Downregulating Tumor-Associated Macrophages in Breast Cancer

• Main Authors: Carla Jorquera-Cordero (Author), Pablo Lara (Author), Luis J. Cruz (Author), Timo Schomann (Author), Anna van Hofslot (Author), Thaís Gomes de Carvalho (Author), Paulo Marcos Da Matta Guedes (Author), Laura Creemers (Author), Roman I. Koning (Author), Alan B. Chan (Author), Raimundo Fernandes de Araujo Junior (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the main reasons for cancer's low clinical response to chemotherapeutics is the highly immunosuppressive tumor microenvironment (TME). Tumor-ass ociated M2 macrophages (M2-TAMs) orchestrate the immunosuppression, which favors tumor progression. Extracellular vesicles (EVs) have shown gre...