Protective role of N-acetyl-l-tryptophan against hepatic ischemia-reperfusion injury via the RIP2/caspase-1/IL-1β signaling pathway

• Main Authors: Jianxin Wang (Author), Shuna Yu (Author), Jianguo Li (Author), Huiting Li (Author), Hongxin Jiang (Author), Peilun Xiao (Author), Yitong Pan (Author), Jie Zheng (Author), Li Yu (Author), Jiying Jiang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context: Hepatic ischemia-reperfusion injury (HIRI) is a complex process observed during liver resection and transplantation. N-acetyl-l-tryptophan (l-NAT), an antagonist of neurokinin 1 receptor, has been used for the treatment of nausea and neurodegenerative diseases. Objective: This study investi...