Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition of ceramide generation

• Main Authors: Pengcheng Wang (Author), Guangyi Zeng (Author), Yu Yan (Author), Song-yang Zhang (Author), Yongqiang Dong (Author), Yangming Zhang (Author), Xingzhong Zhang (Author), Huiying Liu (Author), Zhipeng Zhang (Author), Changtao Jiang (Author), Yanli Pang (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atherosclerosis is a chronic multifactorial cardiovascular disease. Western diets have been reported to affect atherosclerosis through regulating adipose function. In high cholesterol diet-fed ApoE-/- mice, adipocyte HIF-1α deficiency or direct inhibition of HIF-1α by the selective pharmacological H...