Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration

• Main Authors: Mara C. Ebeling (Author), Zhaohui Geng (Author), Madilyn R. Stahl (Author), Rebecca J. Kapphahn (Author), Heidi Roehrich (Author), Sandra R. Montezuma (Author), Deborah A. Ferrington (Author), James R. Dutton (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. No universally effective treatments exist for atrophic or "dry" AMD, which results from loss of the retinal pigment epithelium (RPE) and photoreceptors and accounts for ≈80% of all AMD patients. Prior...