QT PRODACT: In Vivo QT Assay in the Conscious Dog for Assessing the Potential for QT Interval Prolongation by Human Pharmaceuticals

• Main Authors: Shigeki Toyoshima (Author), Akihiro Kanno (Author), Tetsuya Kitayama (Author), Koji Sekiya (Author), Keiko Nakai (Author), Masao Haruna (Author), Terumasa Mino (Author), Hiroyasu Miyazaki (Author), Koji Yano (Author), Keiji Yamamoto (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The goal of the present study was to examine the utility of the conscious dog model by assessing the QT-interval-prolonging potential of ten positive compounds that have been reported to induce QT interval prolongation in clinical use and seven negative compounds considered not to have such an effec...