Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples

• Main Authors: Nacu Serban (Author), Yuan Wenlin (Author), Kan Zhengyan (Author), Bhatt Deepali (Author), Rivers Celina (Author), Stinson Jeremy (Author), Peters Brock A (Author), Modrusan Zora (Author), Jung Kenneth (Author), Seshagiri Somasekar (Author), Wu Thomas D (Author)
• Format: Book
• Published: BMC, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Readthrough fusions across adjacent genes in the genome, or transcription-induced chimeras (TICs), have been estimated using expressed sequence tag (EST) libraries to involve 4-6% of all genes. Deep transcriptional sequencing (RNA-Se...