Development of Analytical Quality by Design Compliant Chaotropic Chromatography Method for Ziprasidone and Its Five Impurities Determination

• 主要な著者: Milena Rmandić (著者), Đorđe Vasilić (著者), Marija Rašević (著者), Mira Zečević (著者), Biljana Otašević (著者), Ana Protić (著者), Anđelija Malenović (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2023-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

In this study, an AQbD-compliant chaotropic chromatography method for ziprasidone and the determination of its five impurities was developed. The influence of critical method parameters (initial and final methanol fraction in the mobile phase, gradient duration) on the set of selected critical metho...