Development of Analytical Quality by Design Compliant Chaotropic Chromatography Method for Ziprasidone and Its Five Impurities Determination

• Main Authors: Milena Rmandić (Author), Đorđe Vasilić (Author), Marija Rašević (Author), Mira Zečević (Author), Biljana Otašević (Author), Ana Protić (Author), Anđelija Malenović (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, an AQbD-compliant chaotropic chromatography method for ziprasidone and the determination of its five impurities was developed. The influence of critical method parameters (initial and final methanol fraction in the mobile phase, gradient duration) on the set of selected critical metho...