mRNA-engineered mesenchymal stromal cells expressing CXCR2 enhances cell migration and improves recovery in IBD

• Main Authors: Qiaojia Li (Author), Yufan Lian (Author), Yiwen Deng (Author), Jieying Chen (Author), Tao Wu (Author), Xinqiang Lai (Author), Bowen Zheng (Author), Chen Qiu (Author), Yanwen Peng (Author), Weiqiang Li (Author), Andy Peng Xiang (Author), Xiaoran Zhang (Author), Jie Ren (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Mesenchymal stromal cells (MSCs) have shown significant heterogeneity in terms of therapeutic efficacy for inflammatory bowel disease (IBD) treatment, which may be due to an insufficient number of MSCs homing to the damaged tissue of the colon. Engineering MSCs with specific chemokine recep...