Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor

• Main Authors: Shouyuan Sun (Author), Tao Shi (Author), Yan Peng (Author), Honghua Zhang (Author), Linsheng Zhuo (Author), Xue Peng (Author), Qien Li (Author), Manxia Wang (Author), Shuzhi Wang (Author), Zhen Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inspired by the crucial roles of (hetero)aryl rings in cholinesterase inhibitors and the pyrrole ring in new drug discovery, we synthesized 19 pyrrole derivatives and investigated their cholinesterase inhibitory activity. As a result, compounds 3o, 3p, and 3s with a 1,3-diaryl-pyrrole skeleton showe...