Role of lipotoxicity in insulin resistance in subtotally nephrectomized mouse model

• Autores principales: Laetitia Koppe (Autor), Caroline Pelletier (Autor), Roxane Vella (Autor), Denis Fouque (Autor), Fitsum Guebre-Egziahber (Autor), Christophe Soulage (Autor)
• Formato: Libro
• Publicado: The Korean Society of Nephrology, 2012-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Chronic kidney disease (CKD) is associated with a large range of metabolic alterations among which insulin resistance and dyslipidemia. We hypothesize that a phenomenon of lipotoxicity and ectopic fat redistribution could be responsible for the insulin-resistance associated to CKD. C57BL/6 mice unde...