Distinguishing Molecular Properties of OAT, OATP, and MRP Drug Substrates by Machine Learning

• প্রধান লেখক: Anisha K. Nigam (Author), Jeremiah D. Momper (Author), Anupam Anand Ojha (Author), Sanjay K. Nigam (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2024-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The movement of organic anionic drugs across cell membranes is partly governed by interactions with SLC and ABC transporters in the intestine, liver, kidney, blood-brain barrier, placenta, breast, and other tissues. Major transporters involved include organic anion transporters (OATs, SLC22 family),...