Distinguishing Molecular Properties of OAT, OATP, and MRP Drug Substrates by Machine Learning
The movement of organic anionic drugs across cell membranes is partly governed by interactions with SLC and ABC transporters in the intestine, liver, kidney, blood-brain barrier, placenta, breast, and other tissues. Major transporters involved include organic anion transporters (OATs, SLC22 family),...
Saved in:
Main Authors: | Anisha K. Nigam (Author), Jeremiah D. Momper (Author), Anupam Anand Ojha (Author), Sanjay K. Nigam (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2024-04-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease
by: Anisha K. Nigam, et al.
Published: (2021) -
Transporters (OATs and OATPs) contribute to illustrate the mechanism of medicinal compatibility of ingredients with different properties in yuanhuzhitong prescription
by: Ze Wang, et al.
Published: (2020) -
Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
by: Irina E. Antonescu, et al.
Published: (2020) -
Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel
by: Yanrong Ma, et al.
Published: (2023) -
Regulatory guidelines do not accurately predict tolvaptan and metabolite interactions at BCRP, OATP1B1, and OAT3 transporters
by: Susan E. Shoaf, et al.
Published: (2021)