Small-molecule compounds inhibiting S-phase kinase-associated protein 2: A review

• Main Authors: Jia Jing (Author), Li Rui (Author), Sun Junyuan (Author), Yang Jinfeng (Author), Hong Zhihao (Author), Lu Weiguo (Author), Jia Zhenyu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

S-phase kinase-associated protein 2 (Skp2) is a substrate-specific adaptor in Skp1-CUL1-ROC1-F-box E3 ubiquitin ligases and widely regarded as an oncogene. Therefore, Skp2 has remained as an active anticancer research topic since its discovery. Accordingly, the structure of Skp2 has been solved and...