Preclinical evaluation of an 18F-labeled N ε-acryloyllysine piperazide for covalent targeting of transglutaminase 2

• Main Authors: Robert Wodtke (Author), Markus Laube (Author), Sandra Hauser (Author), Sebastian Meister (Author), Friedrich-Alexander Ludwig (Author), Steffen Fischer (Author), Klaus Kopka (Author), Jens Pietzsch (Author), Reik Löser (Author)
• Format: Book
• Published: SpringerOpen, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Transglutaminase 2 (TGase 2) is a multifunctional protein and has a prominent role in various (patho)physiological processes. In particular, its transamidase activity, which is rather latent under physiological conditions, gains importance in malignant cells. Thus, there is a gre...