Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

• Main Authors: Mengqing Jiang (Author), Xuejing Sun (Author), Suzhen Liu (Author), Yan Tang (Author), Yunming Shi (Author), Yuanyuan Bai (Author), Yujie Wang (Author), Qiong Yang (Author), Qize Yang (Author), Weihong Jiang (Author), Hong Yuan (Author), Qixia Jiang (Author), Jingjing Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Pyroptosis is a form of cell death triggered by proinflammatory signals. Recent studies have reported that oxidized phospholipids function as caspase-11 agonists to induce noncanonical inflammasome activation in immune cells. As the levels of oxidized phospholipids derived from ox-LDL ar...