Impact of Small Molecules Immunosuppressants on P-Glycoprotein Activity and T-cell Function

• Main Authors: Inés Llaudó (Author), Linda Cassis (Author), Joan Torras (Author), Oriol Bestard (Author), Marcel·la Franquesa (Author), Josep M. Cruzado (Author), Gema Cerezo (Author), Esther Castaño (Author), Jordi Petriz (Author), Immaculada Herrero-Fresneda (Author), Josep M. Grinyó (Author), Núria Lloberas (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. P-glycoprotein (Pgp) is a member of the ABC-transporter family that transports substances across cellular membranes acting as an efflux pump extruding drugs out of the cells. Pgp plays a key role on the pharmacokinetics of several drugs. Herein, we have studied the effects of immunosuppress...