Comparing the Variants of Iron Oxide Nanoparticle-Mediated Delivery of miRNA34a for Efficiency in Silencing of PD-L1 Genes in Cancer Cells

• Main Authors: Richa Pandey (Author), Feng-Shuo Yang (Author), Vyshnav Punnath Sivasankaran (Author), Yu-Lun Lo (Author), Yi-Ting Wu (Author), Chia-Yu Chang (Author), Chien-Chih Chiu (Author), Zi-Xian Liao (Author), Li-Fang Wang (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The blocking of programmed death-ligand 1 (PD-L1) in tumor cells represents a powerful strategy in cancer immunotherapy. Using viral vectors to deliver the cargo for inactivating the PD-L1 gene could be associated with host cell genotoxicity and concomitant immune attack. To develop an alternative s...