No evidence for age-related differences in mitochondrial RNA quality in the female germline

• Main Authors: Fiona Hartley (Author), Arwa Alageel (Author), Ruth Appeltant (Author), Nicki Gray (Author), Emmanouela Repapi (Author), Dagan Wells (Author), Suzannah A Williams (Author), Joanna Poulton (Author)
• Format: Book
• Published: Bioscientifica, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial quality is implicated as a contributor to declining fertility with aging. We investigated mitochondrial transcripts in oocytes and their associated cumulus cells from mice of different ages using RNA-seq. Mice aged 3 weeks, 9 weeks, and 1 year were superovulated, and 48 h later, oocyte...