High salt loading induces urinary storage dysfunction via upregulation of epithelial sodium channel alpha in the bladder epithelium in Dahl salt-sensitive rats

• Main Authors: Seiji Yamamoto (Author), Yuji Hotta (Author), Kotomi Maeda (Author), Tomoya Kataoka (Author), Yasuhiro Maeda (Author), Takashi Hamakawa (Author), Yasuhiro Shibata (Author), Shoichi Sasaki (Author), Shinya Ugawa (Author), Takahiro Yasui (Author), Kazunori Kimura (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We aimed to investigate whether high salt intake affects bladder function via epithelial sodium channel (ENaC) by using Dahl salt-resistant (DR) and salt-sensitive (DS) rats. Bladder weight of DR + high-salt diet (HS, 8% NaCl) and DS + HS groups were significantly higher than those of DR + normal-sa...